Immunogenetic factors and chronic low grade inflammation in pathomechanisms of autism and their correlations with gastrointestinal dysfunction and behavioural markers VEGA 1/0141/17, principal investigator: doc. MUDr. Katarína Babinská, PhD., MSc.
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Compared to the general population, individuals with autism have been diagnosed with a dysregulation of the immune system with the possibility of serious effects on the overall health of these individuals. The role of the immune system, especially the involvement of pro-inflammatory cytokines, which also affect the function of certain brain structures and thus patient
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The ratio of boys to girls with an autistic phenotype is approximately 4: 1, suggesting the involvement of genes on the Y sex chromosome and male sex hormones in the etiology of autism. Sex hormones significantly modulate brain activity at certain developmental stages with cognitive consequences that we observe in the behavioral and cognitive characteristics
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