The impact of COVID-19 pandemic on mental health of Slovak families with children with autism spectrum disorder and families with typically developing children The research aimed to monitor changes in the mental health of families with children with autism spectrum disorder (ASD) as well as families with neurotypical children, from first to third wave of
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Autism is a neurodevelopmental disorder, the responsible factors that increase the risk of this disorder exert their effects already during the prenatal period. Dermatoglyphs (formations that are formed by a unique arrangement of papillary lines – fingerprints are most often described) and their asymmetry are a reflection of developmental instability / instability during embryogenesis. Developmental
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The mechanical properties of the erythrocyte membrane are very important clinical indicators. Deformability is the ability of erythrocytes to pass through thin capillaries without damage. Its disorder can lead to the pathogenesis of several diseases, including ASD. More Examination of erythrocyte deformability in relation to the clinical manifestations of autism in children. In this study,
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The pathomechanisms of ASD have not yet been elucidated; metabolic disorders may play a role. Thanks to innovative methods such as the mass spectrometry and the statistical possibilities of large-scale data analysis, the metabolomics method is finding an increasingly widespread application in current medical research. Metabolomics involves the determination of the concentration of endogenous molecules
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Compared to the general population, individuals with autism have been diagnosed with a dysregulation of the immune system with the possibility of serious effects on the overall health of these individuals. The role of the immune system, especially the involvement of pro-inflammatory cytokines, which also affect the function of certain brain structures and thus patient
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Children with ASD often have trouble sleeping. Their causes can be different, one of the theories assumes disruption of circadian rhythms (so-called internal biological clocks). This theory is evidenced by the differences in the levels of melatonin – a hormone that is involved in the regulation of biorhythms depending on changes in light intensity during
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Compared to the general healthy population, people with autism have a higher incidence of associated disorders that have serious implications for the individual’s overall condition and prognosis. Many people with autism spectrum disorders suffer from disorders of the digestive system. In ASD, they occur more frequently than in the general population. Studies report their presence
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Research in recent years has enriched the knowledge about the intestinal microbiota and the gut-brain axis through which the microbiota can affect the brain. An increasing number of studies point to intestinal dysbiosis – a different microbial population – as one of the possible factors involved in the development of ASD. In the project we
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In genetic projects, we perform an analysis of selected genetic markers in phenotypically homogeneous individuals due to the high heterogeneity of the spectrum of autistic disorders. We focus on the analysis of selected genetic markers in phenotypically homogeneous individuals due to the large heterogeneity of ASD people. The goal of such oriented autism research
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Passive smoking, or otherwise called secondary smoking, is now a serious problem affecting non-smokers in households and public places. Prenatal nicotine exposure can cause neurotoxic and neuromodulatory effects on the brain that lead to modifications in healthy development. … More Consequences of passive smoking on adaptive behavior of children with ASD In the study, we
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