In genetic projects, we perform an analysis of selected genetic markers in phenotypically homogeneous individuals due to the high heterogeneity of the spectrum of autistic disorders. We focus on the analysis of selected genetic markers in phenotypically homogeneous individuals due to the large heterogeneity of ASD people. The goal of such oriented autism research
Passive smoking, or otherwise called secondary smoking, is now a serious problem affecting non-smokers in households and public places. Prenatal nicotine exposure can cause neurotoxic and neuromodulatory effects on the brain that lead to modifications in healthy development. … More Consequences of passive smoking on adaptive behavior of children with ASD In the study, we
Oxytocin as a prosocial hormone affects relationships, empathy, socialization but also the protection of offspring. In the projects, we monitor oxytocin levels in children with ASD in comparison with the general population, as well as selected genetic polymorphisms of the oxytocin receptor gene and determine the association of oxytocin with behavioral characteristics. The effect of
Following the verification of the effect of testosterone and its metabolites, we find out whether other steroid hormones such as mineralocorticoids or glucocorticoids also interfere with the pathogenesis of autism. The involvement of these hormones has not yet been precisely elucidated. The aim of the project is a comprehensive analysis of the steroid metabolism in
The ratio of boys to girls with an autistic phenotype is approximately 4: 1, suggesting the involvement of genes on the Y sex chromosome and male sex hormones in the etiology of autism. Sex hormones significantly modulate brain activity at certain developmental stages with cognitive consequences that we observe in the behavioral and cognitive characteristics
In individuals with ASD, we assess the overall rate of autism as well as the depth of deficits in the triad of impairment using ADI-R ADOS-2 diagnostic tools. The development of diagnostic methods and the experience gained over the years by a team of certified experts represent significant outputs for both scientific research and
In our research center we use standard screening (MCHAT) and diagnostic (ADOS2, ADI-R) tools for the diagnosis of autism spectrum disorders. We use standard rating scales to detect aggressive behavior, adaptive behavior, GIT difficulties and cognitive abilities. Verification of the effectiveness of the M-CHAT questionnaire in the Slovak population and introduction of mandatory ASD screening
