![Sex-dependent effects of letrozole on anxiety in middle-aged rats](https://acva.sk/wp-content/uploads/2017/06/Sex-dependent-effects-of-letrozole-600x400.png)
AUTHORS: Borbelyova, V., E. Renczes Domonkos, M. Csongova, M. Kacmarova, D. Ostatnikova, P. Celec, and J. Hodosy ABSTRACT: Aromatase catalyzes the conversion of testosterone to estradiol and is involved in the physiological effects of sex hormones on brain function. Animal experiments have shown that the aromatase inhibitor, letrozole, can induce anxiety in young ovariectomized females