2020 | Akademické centrum výskumu autizmu

1. DECEMBER 2020

Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model

AUTHORS: Reichová, A., Bačová, Z., Bukatová, S., Kokavcová, M., Melišková, V., Frimmel, K., Ostatníková, D. and Bakoš, J. ABSTRACT: Oxytocin has been suggested as a potential therapeutic agent in autism and other neuropsychiatric conditions. Although, the link between the deficit in “SH3 domain and ankyrin repeat containing protein 3” (SHANK3) and autism spectrum disorders is

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2. NOVEMBER 2020

A novel UHPLC-MS method targeting urinary metabolomic markers for autism spectrum disorder

AUTHORS: Olešová, D., Galba, J., Piešťanský, J., Celušáková, H., Repiská, G., Babinská, K., Ostatníková, D., Katina, S. and Kováč, A. ABSTRACT: Autism spectrum disorder is a heterogeneous neurodevelopmental disease. Currently, no biomarker of this disease is known. Diagnosis is performed through observation, standardized behavioral scales, and interviews with parents. In practice, diagnosis is often delayed

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25. OCTOBER 2020

Detection of disease-associated microRNAs – application for autism spectrum disorders

AUTHORS: Konečná, B., Radošinská, J., Keményová, P. and Repiská, G. ABSTRACT: Autism spectrum disorders (ASD) diagnostic procedure still lacks a uniform biological marker. This review gathers the information on microRNAs (miRNAs) specifically as a possible source of biomarkers of ASD. Extracellular vesicles, and their subset of exosomes, are believed to be a tool of cell-to-cell

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6. OCTOBER 2020

Testosterone and the brain: from cognition to Autism

AUTHORS: Ostatníková, D., Lakatošová, S., Babková, J., Hodosy, J. and Celec, P. ABSTRACT: Sex and gender matter in all aspects of life. Humans exhibit sexual dimorphism in anatomy, physiology, but also pathology. Many of the differences are due to sex chromosomes and, thus, genetics, other due to endocrine factors such as sex hormones, some are

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23. SEPTEMBER 2020

Autism specrum disorders symptoms in pre-school girls (Špecifiká prejavov porúch autistického spektra u dievčat predškolského veku)

AUTHORS: Čelárová, D., Celušáková, H., Szapuová, Ž. and Ostatníková, D. ABSTRACT: Autism spectrum disorders are more common in males than females. Cause of this ratio is unknown and has been ascribed to hormonal (extreme male brain theory) or genetic (female protective model) etiology. One of the plausible explanations is the ability of girls to better

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1. SEPTEMBER 2020

Do „autistic traits“ determine our career choice?

AUTORI: Kyselicová, K., Čelárová, D., Celušáková, H., Janšáková, K., Greguš, M., Neščáková, E., Ostatníková, D. ABSTRACT: Objectives: Autistic traits may display a continuous distribution throughout the population. The aim of the present study was to assess the prevalence of autistic traits in university students and look for possible cognitive or behavioral differences between students ofViac

1. AUGUST 2020

Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns

AUTHORS: Sashova Tomova, A., Soltys, K., Repiska, G., Palkova, L., Celarova, D., Minarik, G., Turna, J., Prochotska, K., Babinska, K., Ostatnikova, D ABSTRACT: Recent research suggests the involvement of bidirectional gut-brain axis in autism spectrum disorder (ASD). The aim of this study was to establish the role of changed gut microbiota in behavioural and gastrointestinalViac

1. JUNE 2020

Gastrointestinal symptoms and feeding problems and their associations with dietary interventions, food supplement use and behavioral characteristics in a sample of children and adolescents with autism spectrum disorders

AUTHORS: Babinska, K., Celusakova, H., Belica, I., Szapuova, Z., Waczulikova, I., Nemcsicsova, D., Tomova, A., Ostatnikova, D. ABSTRACT: Autism spectrum disorders (ASD) are characterized by impairments in social interaction, communication, and restricted, stereotyped behavior. Gastrointestinal (GI), nutritional, and feeding problems are often reported in ASD. We investigated the prevalence of GI symptoms, food selectivity, andViac

1. MAY 2020

Gastrointestinal symptoms and feeding problems and their association with dietary interventions, food supplement use and behavioral characteristics in a sample of children and adolescents with autism spectrum disorders.

AUTORI: Babinska, K., Celusakova, H., Belica I., Szapuova, Z., Waczulikova, I., Nemcsicsova, D., Sashova Tomova, A., Ostatnikova, D. International Journal of Environmental Research and Public Health, 2020. 17(17): p. 1-18 https://www.mdpi.com/1660-4601/17/17/6372/htmViac

1. MAY 2020

A Novel UHPLC-MS Method Targeting Urinary Metabolomic Markers for Autism Spectrum Disorder

AUTHORS: Olesova, D., Galba, J., Piestansky, J., Celusakova, H., Repiska, G., Babinska, K., Ostatnikova, D., Katina, S., Kovac, A.. ABSTRACT: Autism spectrum disorder is a heterogeneous neurodevelopmental disease. Currently, no biomarker of this disease is known. Diagnosis is performed through observation, standardized behavioral scales, and interviews with parents. In practice, diagnosis is often delayed toViac