{"id":25084,"date":"2025-04-09T20:13:12","date_gmt":"2025-04-09T18:13:12","guid":{"rendered":"https:\/\/acva.sk\/examining-erythrocytes-as-potential-blood-biomarkers-forautism-spectrum-disorder-their-relationship-to-symptomseverity-and-adaptive-behavior\/"},"modified":"2025-06-24T16:58:52","modified_gmt":"2025-06-24T14:58:52","slug":"examining-erythrocytes-as-potential-blood-biomarkers-forautism-spectrum-disorder-their-relationship-to-symptomseverity-and-adaptive-behavior","status":"publish","type":"post","link":"https:\/\/acva.sk\/en\/examining-erythrocytes-as-potential-blood-biomarkers-forautism-spectrum-disorder-their-relationship-to-symptomseverity-and-adaptive-behavior\/","title":{"rendered":"Examining Erythrocytes as Potential Blood Biomarkers forAutism Spectrum Disorder: Their Relationship to SymptomSeverity and Adaptive Behavior"},"content":{"rendered":"\n<p>AUTHORS: Jasenovec, T., Rado\u0161insk\u00e1, D., Belica, I., Ra\u0161kov\u00e1, B., P\u00fazserov\u00e1, A., Vrbjar, N., Rado\u0161insk\u00e1, J.<\/p>\n\n<p>ABSTRACT: Background: Multiple research teams have documented various abnormalities in erythrocyte properties in children with autism spectrum disorder (ASD) compared with neurotypical<br\/>individuals. Reduced erythrocyte deformability, a crucial factor for microcirculation and oxygen delivery, may affect brain function. Other key factors like nitric oxide (NO) and Na,K-ATPase regulated cation transport also play roles in both erythrocyte deformability and ASD, suggesting a possible relationship between erythrocyte parameters and autism severity. Thus, this study aims to describe these associations, exploring erythrocyte properties as potential biomarkers in ASD. Methods: A total of 179 ASD children were enrolled in this study. Diagnosis was confirmed by the Autism Diagnostic Observation Schedule\u2014Second Edition (ADOS-2) and Autism Diagnostic Interview-Revised. The Vineland Adaptive Behavior Scales, Third Edition (VABS-3), was used to assess adaptive behavior. RBC deformability was measured using a filtration technique, while NO production by RBCs was assessed via DAF-2DA fluorescence. Na,K-ATPase kinetics and RBC osmotic resistance were evaluated spectrophotometrically. Results: Children with more severe ASD symptoms had more impaired deformability and osmotic resistance than children with mild symptoms. Higher RBC NO production was linked to better scores in some VABS-3 subdomains, and in the social affect domain of ADOS-2. Higher affinity of Na,K-ATPase for sodium negatively correlated with the occurrence of repetitive and restricted behavior\u2014one of the core ASD symptoms. Conclusions: This study identified potential links between ASD severity and RBC properties. While erythrocyte quality can influence ASD symptomatology, the observed relationships\u2014such as those involving RBC deformability, NO production, Na,K-ATPase kinetics, and osmotic resistance\u2014were not strong or consistent enough to be considered reliable diagnostic or prognostic biomarkers.<\/p>\n\n<p>Biomedicines 2024, 12, 2619<\/p>\n\n<p>https:\/\/doi.org\/10.3390\/biomedicines12112619<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AUTHORS: Jasenovec, T., Rado\u0161insk\u00e1, D., Belica, I., Ra\u0161kov\u00e1, B., P\u00fazserov\u00e1, A., Vrbjar, N., Rado\u0161insk\u00e1, J. ABSTRACT: Background: Multiple research teams have documented various abnormalities in erythrocyte properties in children with autism spectrum disorder (ASD) compared with neurotypicalindividuals. Reduced erythrocyte deformability, a crucial factor for microcirculation and oxygen delivery, may affect brain function. Other key factors<\/p>\n","protected":false},"author":5,"featured_media":24868,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[463,107],"tags":[140,167,108],"class_list":["post-25084","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2024-en","category-publications","tag-asd-en","tag-autism-spectrum-disorder-en","tag-publikacie-en"],"_links":{"self":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/25084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/comments?post=25084"}],"version-history":[{"count":1,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/25084\/revisions"}],"predecessor-version":[{"id":25085,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/25084\/revisions\/25085"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/media\/24868"}],"wp:attachment":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/media?parent=25084"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/categories?post=25084"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/tags?post=25084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}