AUTHORS: Jan\u0161\u00e1kov\u00e1, K., Kyselicov\u00e1, K., Ostatn\u00edkov\u00e1, D. and Repisk\u00e1, G.<\/p>\n
ABSTRACT: The diagnostic process for autism spectrum disorders (ASD) is based on a behavioral <\/span>analysis of the suspected individual. Despite intensive research, no specific and valid biomarker <\/span>has been identified for ASD, but saliva, with its advantages such as non-invasive collection, could <\/span>serve as a suitable alternative to other body fluids. As a source of nucleic acid of both human and <\/span>microbial origin, protein and non-protein molecules, saliva offers a complex view on the current <\/span>state of the organism. Additionally, the use of salivary markers seems to be less complicated not only <\/span>for ASD screening but also for revealing the etiopathogenesis of ASD, since enrolling neurotypical <\/span>counterparts willing to participate in studies may be more feasible. The aim of the presented review <\/span>is to provide an overview of the current research performed on saliva in relation to ASD, mutual <\/span>complementing, and discrepancies that result in difficulties applying the observed markers in clinical <\/span>practice. We emphasize the methodological limitations of saliva collection and processing as well as <\/span>the lack of information regarding ASD diagnosis, which is critically discussed.<\/span><\/p>\n