{"id":22062,"date":"2021-12-30T07:55:00","date_gmt":"2021-12-30T06:55:00","guid":{"rendered":"https:\/\/acva.sk\/the-role-of-selected-postsynaptic-scaffolding-proteins-at-glutamatergic-synapses-in-autism-related-animal-models\/"},"modified":"2022-08-22T12:50:09","modified_gmt":"2022-08-22T10:50:09","slug":"the-role-of-selected-postsynaptic-scaffolding-proteins-at-glutamatergic-synapses-in-autism-related-animal-models","status":"publish","type":"post","link":"https:\/\/acva.sk\/en\/the-role-of-selected-postsynaptic-scaffolding-proteins-at-glutamatergic-synapses-in-autism-related-animal-models\/","title":{"rendered":"The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models"},"content":{"rendered":"<p>AUTHORS: Meli\u0161kov\u00e1, V., Havr\u00e1nek, T., Ba\u010dov\u00e1, Z. and Bako\u0161, J.<\/p>\n<p>ABSTRACT: <span dir=\"ltr\" role=\"presentation\">Pathological changes in synapse formation, plasticity and devel<\/span><span dir=\"ltr\" role=\"presentation\">opment are caused by altered trafficking and assembly of postsy<\/span><span dir=\"ltr\" role=\"presentation\">naptic scaffolding proteins at sites of glutamatergic and gamma-<\/span><span dir=\"ltr\" role=\"presentation\">aminobutyric acid synapses, suggesting their involvement in the eti<\/span><span dir=\"ltr\" role=\"presentation\">ology of neurodevelopmental disorders, including autism. Several <\/span><span dir=\"ltr\" role=\"presentation\">autism-related mouse models have been developed in recent years <\/span><span dir=\"ltr\" role=\"presentation\">for studying molecular, cellular and behavioural defects to under<\/span><span dir=\"ltr\" role=\"presentation\">stand the etiology of autism and test potential treatment strategies. <\/span><span dir=\"ltr\" role=\"presentation\">In this review, the role of alterations in selected postsynaptic scaf<\/span><span dir=\"ltr\" role=\"presentation\">folding proteins in relevant transgene autism-like mouse models is <\/span><span dir=\"ltr\" role=\"presentation\">explained. A summary is also provided of selected animal models by <\/span><span dir=\"ltr\" role=\"presentation\">paying special attention to interactions between guanylate kinases <\/span><span dir=\"ltr\" role=\"presentation\">or membrane-associated guanylate kinases, as well as other synapse <\/span><span dir=\"ltr\" role=\"presentation\">protein components which form functional synaptic networks. The <\/span><span dir=\"ltr\" role=\"presentation\">study of early developmental stages of autism-relevant animal mod<\/span><span dir=\"ltr\" role=\"presentation\">els help in the understanding the origin and development of diverse <\/span><span dir=\"ltr\" role=\"presentation\">autistic symptomatology.<\/span><\/p>\n<p><i data-v-28679d4d=\"\">J. Integr. Neurosci.<\/i> 2021 , 20(4), 1047\u2013105<\/p>\n<p><a href=\"https:\/\/doi.org\/10.31083\/j.jin2004106\">https:\/\/doi.org\/10.31083\/j.jin2004106<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AUTHORS: Meli\u0161kov\u00e1, V., Havr\u00e1nek, T., Ba\u010dov\u00e1, Z. and Bako\u0161, J. ABSTRACT: Pathological changes in synapse formation, plasticity and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gamma-aminobutyric acid synapses, suggesting their involvement in the etiology of neurodevelopmental disorders, including autism. Several autism-related mouse models have been<\/p>\n","protected":false},"author":5,"featured_media":21926,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_eb_attr":"","footnotes":""},"categories":[341,107],"tags":[140,167,346,345,344,342,343],"class_list":["post-22062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2021-en","category-publications","tag-asd-en","tag-autism-spectrum-disorder-en","tag-contactin-associated-protein-like-2-cntnap2-en","tag-fragile-x-mental-retardation-protein-fmrp-en","tag-homer1-en","tag-scaffolding-proteins-en","tag-sh3-domain-and-ankyrin-repeat-containing-proteins-shanks-en"],"_links":{"self":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/22062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/comments?post=22062"}],"version-history":[{"count":1,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/22062\/revisions"}],"predecessor-version":[{"id":23035,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/posts\/22062\/revisions\/23035"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/media\/21926"}],"wp:attachment":[{"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/media?parent=22062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/categories?post=22062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/acva.sk\/en\/wp-json\/wp\/v2\/tags?post=22062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}