AUTHORS: Babinska, K., Tomova, A., Celusakova, H., Babkova, J., Repiska, G., Kubranska, A., Filcikova, D., Siklenkova, L., and Ostatnikova, D.<\/p>\n
ABSTRACT: Autism<\/span> spectrum<\/span> disorders<\/span> (ASD)<\/span> are<\/span> neurodevelopmental <\/span>disorders<\/span> characterized<\/span> by<\/span> impaired<\/span> social<\/span> interaction<\/span> and <\/span>communication,<\/span> as<\/span> well<\/span> as<\/span> repetitive<\/span> behavior<\/span> and<\/span> restricted <\/span>interests.<\/span> There<\/span> is<\/span> convincing<\/span> evidence<\/span> that<\/span> the<\/span> intestinal <\/span>inflammation is involved in etiology of ASD. Increased levels of <\/span>inflammatory markers were shown to be associated with more <\/span>aberrant<\/span> behaviors<\/span> and<\/span> communication<\/span> of<\/span> subjects<\/span> with<\/span> ASD. <\/span>Calprotectin in the feces is produced by activated neutrophils and <\/span>epithelial cells of the gut mucosa, and its levels reflect local <\/span>inflammation of the gastrointestinal tract. Concentration of fecal <\/span>calprotectin was determined by ELISA method in 87 individuals <\/span>with ASD and 51 controls, of that 29 siblings of children with ASD <\/span>and 22 non-related controls. In non-relatives significantly lower <\/span>values of fecal calprotectin were observed than in both subjects <\/span>with ASD and their siblings. In the group with ASD significant <\/span>correlations<\/span> of<\/span> fecal<\/span> calprotectin<\/span> with<\/span> all<\/span> domains<\/span> of<\/span> the <\/span>ADI-R diagnostic tool were found: qualitative abnormalities in <\/span>reciprocal social interaction and communication, restrictive and <\/span>repetitive patterns of behavior. Results suggest that low grade <\/span>intestinal inflammation may be one of factors implicated in the <\/span>pathophysiology of ASD.<\/span><\/p>\n Physiol Res, 2017. 66(Supplementum 4): p. S517-S522.<\/p>\n