AUTHORS: Jasenovec, T., Radosinska, D., Celusakova, H., Celarova, D., Radosinska, J.<\/p>\n
ABSTRACT: Biomechanical properties of erythrocytes play an important role <\/span>in health and disease. Deformability represents intrinsic property <\/span>of erythrocytes to undergo deformation that is crucial for their <\/span>passage through the narrow capillaries. The erythrocyte damage <\/span>can lead to compromised tissue perfusion and consequently play <\/span>a<\/span> role<\/span> in<\/span> the<\/span> pathogenesis<\/span> of<\/span> various<\/span> diseases<\/span> including <\/span>neurological<\/span> ones.<\/span> Data<\/span> available<\/span> in<\/span> databases<\/span> indicate<\/span> that <\/span>erythrocytes in autism spectrum disorder (ASD) are altered. This <\/span>may affect the clinical symptoms of ASD. The aim of our study <\/span>was to determine erythrocyte deformability in 54 children with <\/span>ASD and correlate it with clinical symptoms. We found significant <\/span>negative correlation between erythrocyte deformability and score <\/span>in C domain of the Autism Diagnostic Interview Revised (ADI-R) <\/span>diagnostic tool describing the measure of restrictive, repetitive, <\/span>and stereotyped behaviors and interests, mainly observable in <\/span>C1 and C2, but not in C3 and C4 subdomains. This supports the <\/span>findings of other authors and suggest that behavioral domain C <\/span>comprises<\/span> of<\/span> more<\/span> subcategories<\/span> with<\/span> different<\/span> underlying <\/span>etiology.<\/span> Our<\/span> results<\/span> also<\/span> indicate<\/span> that<\/span> abnormalities<\/span> in <\/span>erythrocyte deformability may be involved in ASD pathomecha<\/span>nisms<\/span> and<\/span> contribute<\/span> to<\/span> its<\/span> clinical<\/span> manifestation.<\/span> Further <\/span>research is necessary to bring more data and identify erythrocyte <\/span>deformability as prognostic biomarker in ASD.<\/span><\/p>\n Physiol Res, 2019. 68(3) Supplementum: 307-313.<\/p>\n